geriatric medicine papers

Biological age acceleration and the dynamic progression of cardiovascular-kidney-metabolic diseases to multimorbidity, dementia and mortality: A prospective cohort study

This prospective cohort study of over 433,000 UK Biobank participants demonstrates that biological age acceleration significantly increases the risk of transitioning from health to cardiovascular-kidney-metabolic disease, accelerates progression to multimorbidity and dementia, and reduces life expectancy, highlighting its potential as a critical biomarker for early intervention.

zeng, p., Yuan, G.2026-04-07📄 geriatric medicine

Advance Care Planning Documentation Completeness and End-of-Life Care: Trends and Associations Among U.S. Older Adults

Using 2010–2022 Health and Retirement Study data, this study finds that while comprehensive advance care planning documentation is associated with less aggressive end-of-life care and higher hospice enrollment among U.S. older adults, the incremental benefits of having two documents over one are modest and the associations are strongest for those with expected deaths.

Xie, Z., Jacobs, M. M., Liang, J. + 2 more2026-04-07📄 geriatric medicine

Self-reported sleep problems are associated with impaired daily-life gait quality and increased fall risk in older people

This study of 758 older adults demonstrates that self-reported sleep problems are linked to impaired daily-life gait quality and a significantly higher risk of both total and injurious falls, suggesting that sleep issues increase fall risk by disrupting balance control rather than simply reducing walking speed.

van Schooten, K. S., Vakulin, A., Khanal, R. + 3 more2026-04-06📄 geriatric medicine

Systematic Review of Population-Based Studies of Prevalence and Incidence of Aging-Associated Neurodegenerative Diseases in Russia

This systematic review of 20 population-based studies in Russia reveals highly variable prevalence estimates for dementia and Parkinson's disease among adults aged 50 and older, largely driven by differences in diagnostic methods and study designs, while highlighting a critical need for standardized, longitudinal research to inform public health planning.

Okhotion, A., Gorbunova, I., Bolshakov, A.2026-04-06📄 geriatric medicine

A Cerebral Frailty Risk Score Integrating Frailty Index and Neuroimaging for Dementia Prediction in the UK Biobank

This study demonstrates that integrating a frailty index with key neuroimaging markers into a novel Cerebral Frailty Risk Score significantly improves the prediction of incident dementia and mortality in older adults, highlighting the value of combining systemic and cerebral vulnerabilities for risk stratification.

Kan, C. N., Chew, J., Lim, W. S. + 1 more2026-04-04📄 geriatric medicine

When Care Depends on the Caregiver: Lived Experiences of Latino Families Navigating Dementia Care Pathways

This qualitative study of 23 Latino care partners reveals that systemic linguistic, cultural, and structural barriers force families to assume the burdensome role of navigating fragmented dementia care pathways, highlighting an urgent need for interventions that redistribute coordination responsibilities back to the healthcare system.

Mora Pinzon, M. C., Pasqualini, R., Navarro, V. + 3 more2026-04-02📄 geriatric medicine

Multimorbidity Patterns and Associated Factors Among Middle-Aged and Older Adults in China: Evidence from the CHARLS Study

Using data from the 2018 CHARLS study, this research identifies distinct multimorbidity patterns among Chinese adults aged 45 and older, revealing that discordant multimorbidity (involving different disease systems) is more prevalent than concordant forms, is associated with poorer health outcomes and higher healthcare utilization, and is characterized by central clusters of cardiometabolic, arthritis, and digestive diseases.

Wang, Z., Skou, S. T., Chen, Y. + 1 more2026-04-02📄 geriatric medicine

Risk Factors for Cardiovascular Disease in Community-Dwelling Older Adults: The Potential Role of Dual Screening for Chronic Kidney Disease and Sarcopenia

This cross-sectional study of 307 Japanese adults aged 65 and older found that chronic kidney disease, sarcopenia, undernutrition, and low physical activity are independent risk factors for cardiovascular disease, with no significant interaction observed between kidney disease and frailty-related factors.

Nishida, T., Hanamura, I., Honda, S. + 1 more2026-03-31📄 geriatric medicine

Elder-Sim: A Psychometrically Validated Platform for Personality-Stable Elderly Digital Twins

This paper introduces ELDER-SIM, a psychometrically validated platform that combines structured cognitive modeling, long-term memory, and domain-specific fine-tuning to create personality-stable elderly digital twins, effectively mitigating personality drift in LLM-based agents for reliable geriatric care simulations.

Wang, J., Yang, Z., Zhu, Z. + 8 more2026-03-30📄 geriatric medicine

From survival to empowerment: A PLS-SEM analysis of residential aging-suitability for empty-nest seniors in urban China

This study utilizes PLS-SEM analysis of 753 urban Chinese empty-nest seniors to validate a multidimensional Aging-Suitability Index, revealing that while safety and physical design form the essential survival foundation, accessibility primarily drives empowerment through perceived independence, thereby guiding prioritized interventions for aging-in-place.

Liu, X., Peng, Y., Li, H. + 1 more2026-03-26📄 geriatric medicine

A deep-learning based biomarker of systemic cellular senescence burden to predict mortality and health outcomes

This study developed and validated a deep-learning-based composite SASP Score using population proteomics data, demonstrating its effectiveness as a robust biomarker for predicting mortality and chronic disease risk while tracking the impact of interventions like exercise on systemic cellular senescence.

Zhao, S., Kuo, C.-L., Lenze, E. J. + 7 more2026-03-24📄 geriatric medicine

Interest in and feasibility of a dementia prevention program among community-dwelling older adults: a questionnaire survey

This questionnaire survey of nearly 10,000 Japanese older adults reveals that while there is moderate interest in dementia prevention programs—particularly those offering short, 10-minute activities—awareness remains low and individuals with frailty or subjective cognitive decline are less likely to engage, highlighting the need for proactive outreach strategies to bridge the evidence-practice gap.

Kouzuki, M., Tazumi, H., Nakada, N.2026-03-24📄 geriatric medicine

REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect. Rationale and protocol for a trial of biological effect.

The REPROGRAM trial is a randomized study designed to assess whether a three-week course of the geroprotectors Metformin, Fisetin, or Spermidin can reduce senescent cells and reverse other hallmarks of ageing in 60 healthy adults aged 70 and older.

Wilson, D., Acharjee, A., Duggal, N. A. + 18 more2026-03-23📄 geriatric medicine

Pharmacotherapy for Depression in Long-Term Care: A Real-World EHR Study

This retrospective study of over 1.6 million U.S. long-term care residents reveals that while 81.7% of those diagnosed with depression received recommended pharmacotherapy, significant disparities persist, with Black residents and those in socioeconomically vulnerable facilities facing lower odds of treatment.

Saumur, T., Mathers, K. E., Ashraf, H. + 1 more2026-03-16📄 geriatric medicine

Neural Indicators of Motor and Cognitive Functioning in Sarcopenia Using Functional Near-Infrared Spectroscopy

Using functional near-infrared spectroscopy (fNIRS), this study reveals that individuals with sarcopenia exhibit reduced cortical activation in frontal and precentral regions during working memory tasks and compensatory right-hemisphere recruitment during attention tasks, alongside diminished muscle force, highlighting altered neural mechanisms that link motor and cognitive decline in this condition.

Sahin, B. M., Kara, M., Erdogan, K. + 4 more2026-03-10📄 geriatric medicine

Ability to Detect Changes and Minimal Important Difference of Real-World Digital Mobility Outcomes in Proximal Femoral Fracture Patients

This multicenter prospective study establishes the first Minimal Important Difference (MID) values and demonstrates the ability of real-world Digital Mobility Outcomes (DMOs) to detect changes in proximal femoral fracture patients, providing essential guidance for interpreting intervention effects and designing future clinical trials.

Jansen, C.-P., Braun, J., Alvarez, P. + 17 more2026-03-06📄 geriatric medicine

Walking in the Free World: Establishing Normative Trajectories for Ecological Assessment of Robust Gait Variability with Age

This study establishes age-related normative trajectories for real-world gait variability in older adults by applying a robust statistical framework that overcomes the limitations of conventional metrics, thereby providing a more reliable and clinically effective tool for early detection of functional decline and fall risk.

Tan, K. Z., Friganovic, K., Kim, Y. K. + 8 more2026-03-06📄 geriatric medicine

Feasibility of at-home online cognitive screening prior to primary care wellness visits for older adults.

This study demonstrates that self-administered online cognitive screening prior to primary care visits is acceptable to older adults and correlates moderately with in-clinic assessments, though completion rates suggest a need for additional support to fully integrate this method into routine care.

Thompson, L., Eaton, C., Prieto, S. + 13 more2026-03-05📄 geriatric medicine

Dissociating the Nocturnal Physiological Drivers of Agitation Occurrence and Severity in Dementia: An Explanatory Study Using Contactless Sleep Sensing

This study demonstrates that passive under-mattress sleep sensing can identify specific nocturnal physiological markers, such as lower respiratory rate and greater activity instability, which predict the occurrence but not the severity of next-day agitation in dementia patients, offering a promising tool for short-term risk stratification.

Liu, Z., Bono, M., Flisar, A. + 3 more2026-03-02📄 geriatric medicine

Linking Modifiable Risk Factors to Vascular and Neurodegenerative Brain Changes

This cross-sectional study of over 38,000 older adults demonstrates that a cumulative burden of ten modifiable risk factors is associated with vascular and neurodegenerative brain changes, particularly hippocampal atrophy, which in turn mediates the link between these risks and poorer cognitive outcomes.

Khudair, T., Raeesi, S., Kamal, F. + 2 more2026-03-02📄 geriatric medicine